Re-ranking sequencing variants in the post-GWAS era for accurate causal variant identification.

For example, the WTCCC [13] required a marginally significant (p-value<10 −4 ) GWAS SNP to support the evidence at a genome-wide significant imputed SNP.

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In this way, re-ranking keeps highly significant SNPs identified by the naïve ranking and adds a few SNPs that would have otherwise been missed.

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