highly significantp = 0.0001
M+F+A− genes were also significantly overrepresented on the X at a 2-fold expression threshold ( f (X) = 0.26, p = 0.03), and at larger thresholds the effect became highly significant, the frequency of X-linkage reaching 0.50 ( p = 0.0001) and 0.57 ( p = 0.0002) for 5- and 10-fold overexpressed genes, respectively.