Bile acids induce apoptosis selectively in androgen-dependent and -independent prostate cancer cells.

In support of a possible involvement of TGR5 in bile acid-induced cell death, we found a highly significant correlation between the potency of each cytotoxic bile acid in LNCaP cells and its reported EC 50 for induction of TGR5 receptor-mediated luciferase activity ( r = 0.96; n = 4; p < 0.001) in transiently transfected Chinese Ovarian Hamster cells ( Sato et al., 2008 ).

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