Metabolic syndrome in schizophrenia: Differences between antipsychotic-naïve and treated patients.

Two studies[ 16 19 ] reported lower mean fasting total cholesterol and low-density lipoprotein (LDL) levels in S-DN patients, whereas several studies have failed to show any association.[ 17 25 26 ] Spelman et al ., in 2007 comparing 38 S-DN patients with 44 matched healthy controls found no differences in total cholesterol, LDL, HDL, or triglycerides.[ 17 ] Sengupta et al .,[ 25 ] in a study on first episode psychosis (FEP) patients also did not find any lipid derangements except a slight trend of lower HDL levels.

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