As downregulation of SELENBP1 is an early event in LSCC, and renders the human bronchial epithelial cells susceptible to B[a]P-induced carcinogenesis, we suggest that the detection of SELENBP1 expression can be used for monitoring high risk group of LSCC including smokers, and improving the early diagnosis of LSCC, and supplementation of dietary selenium may be significant for the prevention of LSCC.
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The function and significance of SELENBP1 downregulation in human bronchial epithelial carcinogenic process.
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