An in-depth characterization of the major psoriasis susceptibility locus identifies candidate susceptibility alleles within an HLA-C enhancer element.

While further studies will be required to validate the functional impact of individual SNPs, it is noteworthy that our data are entirely consistent with those generated in previous surveys of disease associate regions, which documented a highly significant enrichment of candidate susceptibility alleles within strong enhancer elements [13] , [14] .

also in 132,142 other papers