The fact that yeast cells, which are primitive eukaryotes, share a common mitochondrial target of NSAIDs with mammalian cells is highly significant, because it suggests that mitochondria constitute a unifying, dominant target of NSAID-induced apoptosis in all mammalian cancer cell types.
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The proapoptotic effect of traditional and novel nonsteroidal anti-inflammatory drugs in mammalian and yeast cells.
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