Recent studies aimed at exploring the molecular mechanisms that regulate actin polymerization prior to MMP recruitment have suggested that cortactin phosphorylation is crucial to invadopodia formation and maturation [22] .These findings suggest that Src tyrosine kinase and its substrate cortactin together play highly significant roles in cancer invasion and migration [23] .
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Impact of flavonoids on matrix metalloproteinase secretion and invadopodia formation in highly invasive A431-III cancer cells.
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