Clostridium difficile exposure as an insidious source of infection in healthcare settings: an epidemiological model.

They also include studies that found either borderline significant reduction in CDI (P=0.04, [ 53 ]) or no statistical significance through a reduction in either high-risk drugs or total antimicrobial usage in healthcare settings (respectively, P=0.0597 and P=0.0823, [ 52 ]).

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Following recent evidence of an increasing trend in colonization and disease in individuals who have not recently received antimicrobials [ 8 ], our model allows for the development of CDI without antibiotic involvement.

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