Ingenol mebutate: A novel topical drug for actinic keratosis.

A consistent decline in the number of AK lesions from day 3 to day 29 was observed for all three active treatments, and the difference between active treatments and vehicle was highly significant at day 57 ( p <0.0001) [ Table 1 ].[ 11 ] The severity of local skin reactions in the active treatment groups followed a dose-dependent pattern, peaked between days 3 and 8 then largely resolved by day 15.

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