17 Morphine and methadone have shown a nonsignificant trend toward greater pain relief compared with the TCAs nortriptyline and desipramine. 32 Adverse events included those usually reported with opioid analgesics, including nausea, constipation, dizziness, xerostomia, anorexia, and sedation/somnolence. 31 , 32 Despite the efficacy of opioids, opinion varies about their place in the treatment of PHN.
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Options for treating postherpetic neuralgia in the medically complicated patient.
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