A variant on the kappa opioid receptor gene (OPRK1) is associated with stress response and related drug craving, limbic brain activation and cocaine relapse risk.

The CC group showed no significant increase in cortisol during stress or drug cue exposure, while the CG group showed a highly significant increase in their cortisol response during stress ( t =4.25, df=109, P <0.0001, Cohen's d =1.46) and drug cue ( t =3.04, df=109, P =0.003, Cohen's d =1.04) relative to the neutral condition ( Figure 2 ).

also in 132,142 other papers