Nevertheless, there might be significant conformational differences between adducts, even if the crystal structures of CDDP- and oxaliplatin-GG adducts are similar, e.g., cisplatin could cause a disruption of cellular activity through binding to a more sensitive region of the genome, such as the telomeres [ 29 ].
← all excerpts
Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effects.
1
—
—