Regulation of sulphur assimilation is essential for virulence and affects iron homeostasis of the human-pathogenic mould Aspergillus fumigatus.

When challenging immunosuppressed, leukopenic mice intranasally with conidia of the metRΔ mutant to induce invasive pulmonary aspergillosis, a highly significant (p<0.001) reduction in the virulence capacity of this strain was observed ( Fig. 7A ) with more than 80% of the cohort surviving the infection.

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