highly significantP -value=10 −3
To test this hypothesis, we searched for common motifs in 100 bp windows surrounding the identified MVPs in CS, LGG and CC using the multiple expectation maximization for motif elicitation (MEME) 17 suite and identified the 5′-CDGGRA-3′ motif as highly significant (MEME P -value=10 −3 , discriminative DNA motif discovery (DREME) P -value=7 × 10 −70 ).