MHC class II tetramers made from isolated recombinant α and β chains refolded with affinity-tagged peptides.

The extended peptides retained their binding status in all ten cases; the effect ranged from a two-fold increase to a three-fold decrease in binding affinity, and a highly significant correlation between bindings of H 6 vs. non-H 6 extended peptides was observed ( Table 1 ).

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