Influence of genetic variations on levels of inflammatory markers of healthy subjects at baseline and one week after clopidogrel therapy; results of a preliminary study.

In our small population of healthy volunteers, neither the polymorphism of CYP3A4 gene (IVS10 + 12G > A), nor the P2Y12 receptor gene polymorphism ( H2 allele) were associated with the platelet response to clopidogrel, although there was a slight trend for H2H2 homozygous subjects to being less responders to clopidogrel [ 12 , 13 ].

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