Further supporting the role of inflammation in the spread of vitiligo lesions, Ahn et al ., in an immunohistochemical study from the marginal skin of vitiligo lesions found enhanced expression of epidermal ICAM-1 and CD4 lymphocytes in samples from active vitiligo as compared to stable disease.[ 55 ] In another study, highly significant increases in CD3+, CD4+ and CD8+ T cells were found in margin of vitiligo lesions and these cells were mostly activated CD45RO+ cells of the memory subset.
1
—
—