The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold.

While 0.3 and 1 mg/kg doses of DORA-12 marginally reduced active wake, this change became highly significant at 3 mg/kg, where plasma levels reached 0.20 μM, corresponding to 83% OX 2 R occupancy (Figure 3 , Table 1 ).

also in 132,142 other papers