Study of therapeutic hypothermia (32 to 35°C) for intracranial pressure reduction after traumatic brain injury (the Eurotherm3235Trial): outcome of the pilot phase of the trial.

The most relevant recent systematic review is therefore that by Peterson and colleagues [ 10 ], which found an overall trend towards 25% improved outcome with hypothermia, in trials of sufficient quality (49.4% versus 41.8% favorable outcome, hypothermia versus control, respectively; relative risk (RR) 1.25; 95% confidence interval (CI) 0.96 to 1.62).

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