In the adherent patients ( n =40, including all three treatment groups), the drop in cortisol level (baseline value=109.9 ng/ml±63.8 and 3-month value=96.3 ng/ml±48.5) reached a trend level of significance ( t =1.79; P =0.08) compared with those who were non-adherent ( n =14; the values were respectively 99.1 ± 45.6 and 102±48.9; t =0.21; P =0.8).
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