EGF-induced bronchial epithelial cells drive neutrophil chemotactic and anti-apoptotic activity in asthma.

In HC and Mod/Sev, but not the MA subjects, stimulation of PBECs with EGF enhanced the chemotactic activity when compared to basal-CM (p = 0.021 in HC, 0.093 in MA and 0.010 in Mod/Sev asthma, Table S1); the EGF-CM activity was related to clinical asthma severity as shown by an increasing trend (linear contrast test p = 0.010) ( Figure 2A ).

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