Inhibition of Plk1 and Cyclin B1 expression results in panobinostat-induced G₂ delay and mitotic defects.

The number of metaphases present in the control population peaked at 9 h (11.5%) while cells cultured in 100 nM panobinostat showed a highly significant reduction in metaphase cells (p < 0.0001), confirming the reduced mitotic entry observed by histone H3 phosphorylation.

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