Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells.

Quantification of the midbrain cluster (boxed) showed a highly significant difference between the selamectin-treated and the control ( Figure 11C , n =20, t -test, p<0.001).

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A better-studied example of this family is avermectin (for the structures of selamectin and avermectin, Figure 5A ), which, when tested for its activity in promoting neuronal differentiation, showed a less potent effect than selamectin with a marginal significance achieved at 0.25 μM ( Figure 5B ).

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