18 Highly significant in the context of this article, metformin ameliorates hepatic methotrexate toxicity in experimental animals. 19 Of equal interest for dermatology, metformin as a topical (or systemic) treatment blocks UV-B induced tumor formation in hairless mice 20 and reduces growth of squamous cell carcinoma. 21 As an adjunct to conventional cancer therapy or to prevent relapse more than 40 human trials with metformin are listed in ClinicalTrials.gov ( www.clinicaltrials.gov accessed November 7, 2012).
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A marriage of two "Methusalem" drugs for the treatment of psoriasis?: Arguments for a pilot trial with metformin as add-on for methotrexate.
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