Aging and calorie restriction oppositely affect mitochondrial biogenesis through TFAM binding at both origins of mitochondrial DNA replication in rat liver.

PLoS One · 2013 · PMC3772924 · PMID 24058615

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highly significantno p-value reported

Effectively, by Pearson’s test analysis, we identified a completely novel, highly significant direct correlation between the paired amounts of TFAM-bound mtDNA at these sub-regions in the joined AL-MA and CRO groups.

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