Chronic Ketamine Reduces the Peak Frequency of Gamma Oscillations in Mouse Prefrontal Cortex Ex vivo.

This decrease was of a similar magnitude as observed with the higher ketamine dose when compared across all epochs of analyzed activity at 5 mg/kg, however, it was only significant in epochs 5 and 6 ( t 9 = 2.28, p < 0.05; t 9 = 2.34, p < 0.05, respectively), and reached a trend level of significance in epochs 1, 2, 3, and 4 ( t 9 = 1.87, p = 0.10; t 9 = 1.98, p = 0.08; t 9 = 1.70, p = 0.13; t 9 = 1.75, p = 0.12, respectively). 5 mg/kg ketamine did not lead to a decrease in the GBO power of KA-elicited oscillations (Figure 2 ).

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