High expression of H3K27me3 is an independent predictor of worse outcome in patients with urothelial carcinoma of bladder treated with radical cystectomy.

Biomed Res Int · 2013 · PMC3777191 · PMID 24093096

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Moreover, an imbalance in H3K27 methylation owing to overexpression of EZH2 has been implicated in metastatic prostate and aggressive breast cancers [ 11 , 28 ], in which a highly significant overlap between PRC2- and H3K27me3-occupied genes was observed [ 28 ].

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