Protection against de novo methylation is instrumental in maintaining parent-of-origin methylation inherited from the gametes.

Mol Cell · 2012 · PMC3778900 · PMID 22902559

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highly significantno p-value reported

Of note, the Peg3 and Snrpn ICRs, which are prone to regaining methylation in some Dnmt3L-/+ progeny ( Arnaud et al., 2006 ), were identified as highly significant hypomethylated DMRs (FDR < 0.02) ( Figures S1 C and S1D).

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