No association between gain in body mass index across the life course and midlife cognitive function and cognitive reserve--the 1946 British Birth Cohort study.

Using BMI categories, we found only a nonsignificant trend toward lower verbal fluency scores among women who were underweight at age 20, 26, and 36 years compared with those having normal weight, whereas we found greater, statistically significant, lower verbal fluency scores among those overweight at age 20 years (β = −0.25; 95% CI: −0.49, −0.14) and 26 years (β = −0.22; 95% CI: −0.42, −0.27), but not at 36 years ( P = .133), and among those obese at 20 years (β = −0.50; 95% CI: −0.99, −0.05), 26 years (β = −0.65; 95% CI: −1.08, −0.23), and 36 years (β = −0.40; 95% CI: −0.67, −0.13), compared with those of normal weight.

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