Widespread DNA hypomethylation at gene enhancer regions in placentas associated with early-onset pre-eclampsia.

Mol Hum Reprod · 2013 · PMC3779005 · PMID 23770704

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highly significantno p-value reported

Pyrosequencing A subset of sites with highly significant differences from the array and/or relevance for prenatal screening or hypoxia was followed up by bisulfite pyrosequencing of EOPET samples ( n = 20), other disease states (LOPET ( n = 21) and nIUGR ( n = 17)) and a larger set of controls covering a broad range of gestational ages ( n = 93).

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