ß1 integrin binding phosphorylates ezrin at T567 to activate a lipid raft signalsome driving invadopodia activity and invasion.

Preliminary three color fluorescence confocal microscopy experiments in cells cultured on DQGreen-BSA Matrigel for 6 hrs demonstrated that, indeed, actin was co-localized with cortactin in the areas of observed focal proteolysis of ECM bound DQGreen-BSA in a highly significant manner in Matrigel (data not shown).

also in 132,142 other papers