highly significantP = 2.6 × 10 −6
bottom 1000 associated transcripts for each of the 61 and 43 trans-SNPs, respectively, we find a highly significant enrichment for lower P-values in the top 1000 transcripts (Mann-Whitney, ALSPAC P = 2.6 × 10 −6 and Oxford P=3.8 × 10 −5 ).