Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage.

PLoS Genet · 2013 · PMC3784509 · PMID 24086148

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highly significantno p-value reported

Based on these criteria, the mtDNA from aged individuals show a highly significant ∼5-fold increase in mutational frequency, relative to those obtained from young individuals (Young: 3.7±0.9×10 −6 vs.

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