GC skew at the 5' and 3' ends of human genes links R-loop formation to epigenetic regulation and transcription termination.

In fact, nearly half of the Class II genes mapped to the eight most gene-rich chromosomes, particularly chromosomes 19 and 17, for which they showed highly significant enrichment (data not shown), while Class I promoters were highly enriched on chromosomes 13 and 18, among the most gene-poor chromosomes.

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