Statistical analyses showed that the mean spreading index was 0.36 ± 0.08 for the wild-type virus and 0.13 ± 0.03 for the ΔA36R variant, reflecting highly significant differences in the spreading ability of the two viral strains ( Fig. 1 B ).
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The formin FHOD1 and the small GTPase Rac1 promote vaccinia virus actin-based motility.
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