Functional site plasticity in domain superfamilies.

However, there does not seem to be an obvious trend in the distribution of enzyme superfamilies in terms of functional site coverage of any type.

also in 1,006 other papers

Wilcoxon Rank-Sum tests performed over the enrichment values provided highly significant P-values for all functional site types except IBIS protein–protein interface residues, suggesting that conserved residues are highly enriched in the remaining three types of functional residues when compared to all residues: catalytic residues, nucleic acid binding residues, and small ligand binding residues (see Table 4 ).

also in 132,142 other papers