Quantification of Na+,K+ pumps and their transport rate in skeletal muscle: functional significance.

Another study by the same group showed that the same dose of dexamethasone induced 17% relative increase in α 1 - and α 2 -subunit expression (P < 0.05) in vastus lateralis muscle, a significantly lower exercise-induced net K + release from the thigh muscles and a borderline significant prolongation of time to exhaustion (P = 0.07) ( Nordsborg et al., 2008 ).

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Moreover, two agents shown to stimulate the Na + ,K + pumps in isolated rat soleus muscle, salbutamol ( Clausen and Flatman, 1977 ) and rat calcitonin gene–related peptide (CGRP) ( Andersen and Clausen, 1993 ), both induce a highly significant stimulation of 86 Rb efflux from the same muscle ( Dørup and Clausen, 1994 ).

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