The mutational landscape of phosphorylation signaling in cancer.

Sci Rep · 2013 · PMC3788619 · PMID 24089029

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highly significantp = 2.5e − 92actually significant

ActiveDriver identifies N-terminal mutations in five cancer types as highly significant ( n = 73, FDR p = 2.5e − 92 from ActiveDriver; Fig. 2b ), confirming constitutive activation of CTNNB1 via disrupted phosphorylation as a prevalent driving mechanism of cancer.

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