Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis.

In contrast, Vps34 ablation only caused a decreasing trend in protein degradation through the microautophagy and/or chaperone-mediated autophagy pathways, suggesting that these lysosomal functions are not affected by the lack of Vps34 at this time-point of study ( Figure 6B ).

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