Perturbations to the ubiquitin conjugate proteome in yeast δubx mutants identify Ubx2 as a regulator of membrane lipid composition.

Mol Cell Proteomics · 2013 · PMC3790291 · PMID 23793018

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highly significantp value < 1e-100actually significant

Remarkably, of the 1733 proteins in our data set, 62% were elevated significantly in at least one mutant (62% was highly significant in comparison to the null hypothesis in which peptide ratios are randomly assigned to proteins ( p value < 1e-100)), suggesting that the Cdc48 network has a profound impact on the UPS that is greater than has been previously appreciated.

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