The novel human influenza A(H7N9) virus is naturally adapted to efficient growth in human lung tissue.

mBio · 2013 · PMC3791893 · PMID 24105764

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highly significantno p-value reported

The differences between human and avian H7 viruses became highly significant through the course of infection.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.