A single nucleotide polymorphism associated with hepatitis C virus infections located in the distal region of the IL28B promoter influences NF-κB-mediated gene transcription.

Furthermore, the HCV RdRp activity within cells (with no other HCV proteins present) has been recently shown to be highly significant in generating innate immune responses in liver cells, in causing liver damage and in mediating pro-inflamatory responses that lead to tumorigenesis in both in vitro and in vivo mice models [32] , [33] .

also in 132,142 other papers