CCAR1 promotes chromatin loading of androgen receptor (AR) transcription complex by stabilizing the association between AR and GATA2.

Nucleic Acids Res · 2013 · PMC3794601 · PMID 23887938

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highly significantno p-value reported

Molecular mechanism of CCAR1 co-regulator function Genome-wide ChIP-on-chip and ChIP-Seq studies identified a highly significant overlap of AR and GATA2-binding sites in androgen target genes and showed that GATA2 acts as a pioneer factor in the recruitment of AR to AR binding sites ( 5 , 6 , 17 ).

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