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Flucytosine and cryptococcosis: time to urgently address the worldwide accessibility of a 50-year-old antifungal.

J Antimicrob Chemother · 2013 · PMC3797641 · PMID 23788479

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In addition, there were fewer deaths in the combination arm that almost reached statistical significance at 2 weeks, despite the small size of the study (Figure 3 ). 64 Combination therapy was well tolerated despite more episodes of neutropenia (five versus one, grade III and IV within the first 2 weeks of antifungal therapy), which were rarely treatment limiting and not associated with increased evid

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