Barely Significant
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The coordination of cell growth during fission yeast mating requires Ras1-GTP hydrolysis.

PLoS One · 2013 · PMC3797800 · PMID 24147005

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highly significantno p-value reported
These observations suggest that the downstream effectors of Ras1 differentially require GTP hydrolysis to propagate a response and could be highly significant when we consider the vast array of signal transduction pathways regulated by Ras proteins in mammalian cells.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.