Barely Significant
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Optimization of vaccine responses with an E1, E2b and E3-deleted Ad5 vector circumvents pre-existing anti-vector immunity.

Cancer Gene Ther · 2009 · PMC3800002 · PMID 19229288

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highly significantno p-value reported
Importantly we found a dramatic and highly significant reduction in T cells response against our novel Ad5[E1−, E2−] vector.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.