Despite a definite trend, we were unable to consistently demonstrate an enrichment of associated acH3 within 1 kb downstream of the DARPP-32 transcription start site (TSS) following HDACi treatment of cultured MSNs.
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Induction of DARPP-32 by brain-derived neurotrophic factor in striatal neurons in vitro is modified by histone deacetylase inhibitors and Nab2.
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