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Colon cryptogenesis: asymmetric budding.

PLoS One · 2013 · PMC3804607 · PMID 24205248

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an increasing trendno p-value reported
An increasing trend towards the top of the crypt is also observed for the HO crypt population.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.