Genome-wide association studies (GWAS) have indicated a highly significant polygenic component of schizophrenia risk, possibly involving up to thousands of common alleles of very small effect, at the population level. 71 While early imaging genetics used intermediate phenotypes to assess the impact of single gene variants, recent studies have increasingly tended towards epistatic models of gene interaction.
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Functional neuroimaging and schizophrenia: a view towards effective connectivity modeling and polygenic risk.
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